Compute the vertices: $B = (v, u),$ $C = (-v, u),$ $D = (-v, -u),$ $E = (v, -u)$

The pentagon is a $2v \times 2u$ rectangle plus a triangle; its area factors as $u(u + 3v),$ and $451 = 11 \cdot 41$

Carrying out the reflections, $B = (v, u),$ $C = (-v, u),$ $D = (-v, -u),$ and $E = (v, -u).$ The points $B, C, D, E$ form a rectangle of width $2v$ and height $2u,$ with area $4uv,$ and $A = (u, v)$ sticks out to its right. Triangle $ABE$ has vertical base $BE$ of length $2u$ and horizontal height $u - v,$ so its area is $u(u - v).$

The pentagon’s area is therefore $$\begin{aligned} 4uv + u(u - v) &= u^2 + 3uv \\ &= u(u + 3v) \\ &= 451 = 11 \cdot 41. \end{aligned}$$ Since $0 \lt v \lt u,$ we have $u \lt u + 3v \lt 4u,$ which rules out the factorization $1 \cdot 451.$ So $u = 11$ and $u + 3v = 41,$ giving $v = 10,$ which indeed satisfies $v \lt u.$

Thus $u + v = 11 + 10 = 21.$