Answer: A

Solution:

Both $d$ and $e$ are distinct members of $\{2,3,5,7\},$ and $10d+e$ must also be prime.

Start with the largest possible tens digit. For $d=7,$ the choices $e=5$ and $e=2$ give the composite numbers $75$ and $72,$ while $e=3$ gives the prime $73.$ This produces $n=7\cdot3\cdot73=1533.$

For $d=5,$ the choices $e=7$ and $e=2$ give the composite numbers $57$ and $52,$ while $e=3$ gives only $5\cdot3\cdot53=795.$ Every case with $d\le3$ is at most $3\cdot7\cdot37=777.$ Hence $1533$ is the largest valid value.

The sum of its digits is $1 + 5 + 3 + 3 = 12.$

Thus, the correct answer is A.